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  • The most common adverse effect of metformin is gastrointestinal upset, including diarrhea, cramps, nausea, vomiting and increased flatulence; metformin is more commonly associated with gastrointestinal side effects than most other antidiabetic drugs.[17] The most serious potential side effect of metformin use is lactic acidosis; this complication is very rare, and the vast majority of these cases
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