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  • 3 heteroatoms selected from N, O, S and SO2.Preferred substituted or unsubstituted 5 to 8 membered heterocyclyls having up to 3 heteroatoms selected from N, O, S and SO2 for R1 are 5 or 6 membered saturated or unsaturated heterocyclyls having up to 3 heteroatoms selected from N, O and S such as morpholino, thiomorpholino, thiomorpholino-1-oxide, thiomopholino-1,1-dioxide, NR2-piperazine, 4-hydrox
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