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  • When chemicals such as food additives are tested for toxicity, the metabolites as well as the original compound are identified and tested. 10 Slide 11: Major Categories/Reactions Phase I Phase II Elimination oxidation reduction hydrolysis conjugation synthesis polar very polar 11 Enzymes of Biotransformation: Phase I enzymes : Enzymes of Biotransformation: Phase I enzymes Oxidation (most important
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