The intracellular decoding of Ca2+ signals, created by coordinated influx and efflux of Ca2+ ions is accomplished by an extended family of Ca2+-sensitive enzymes, known as Ca2+ sensors.Importantly, Ca2+ regulation is not uniform throughout the cell, and different compartments, represented by intracellular organelles, such as endoplasmic reticulum or mitochondria, are endowed with the specific Ca2+