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  • The present invention provides the therapeutic effect of BoNTs involve but not be limited to inhibition of the release of sensory afferent/efferent or autonomic efferent and secretory cell derived mediators of inflammation, (e.g. SP, cGRP, 5-HT, VIP, IL-1, IL-2, TNF, NO, NGF and other cytokines and tachykinins) having a longer lasting therapeutic effect (on the order of weeks or months versus curr
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