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  • Alterations in exposure to microorganisms is another plausible explanation, at present, for the increase in atopic allergy.[14] Endotoxin exposure reduces release of inflammatory cytokines such as TNF-??, IFN??, interleukin-10, and interleukin-12 from white blood cells (leukocytes) that circulate in the blood.[47] Certain microbe-sensing proteins, known as Toll-like receptors, found on the surface
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