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  • lesion noun Any of various pathological or traumatic changes in a bodily organ or tissue, including tumors, ulcers, sores, and wounds. transitive verb le??sioned, le??sion??ing, le??sions To cause a lesion to form on or in.Origin of lesion Middle English lesioun, from Old French lesion, from Latin laesi??, laesi??n-, from laesus, past participle of laedere, to injure. lesion Noun (plural lesions)A
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