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  • Platelets also need TXA2 (vasoconstrictor, bronchoconstrictor, platelet aggregator) which they make themselves ( only cell that has TXA synthase). - Prolonged bleeding time : thrombocytopenia < 90,000 or vW disease (AD) - Aspirin inhibit the platelet COX, 9 times stronger than the endothelial COX. - Aspirin is an irreversible inhibitor of COX, other NSAID inhibit it for 48 hours . - Platelet probl
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