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  • Many bacteria produce one or more factors, at least in vitro, which would seem potentially harmful. (As Big Robbins" puts it: All the leukocidins, hemolysins, hyaluronidases, coagulases, fibrinolysins, and other miscellaneous enzymes extracted from bacterial cultures act on their respective substrates in vitro, but their role in human disease remains presumptive.) However, known exotoxins (i.e.
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