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  • Another group of mediators that contribute to macrophage-mediated cytotoxicity and tissueinjury are proinflammatory cytokines including TNF??, IL-1, and IL-6, as well as chemokinessuch as CXCL8 (IL-8), CXCL2 (MIP-2) and CCL2 (MCP-1) [reviewed in (15)].
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