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  • MDMA use has been shown to produce brain lesions, a form of brain damage, in the serotonergic neural pathways of humans and other animals.[2][4] In addition, long-term exposure to MDMA in humans has been shown to produce marked neurotoxicity in serotonergic axon terminals.[18][24][30] Neurotoxic damage to axon terminals has been shown to persist for more than two years.[30] Brain temperature durin
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