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  • Suitable protecting groups are well known to those skilled in the art, and include trimethylsilyl, dirnethylhexylsilyl, t-butyldimethylsilyl, and t-butyldipbenylsilyl, trityl, alkyl groups, acyl groups such as acetyl and propionyl, methanesulfonyl, and p-toluenesulfonyl. [0047] The term biologically active nucleoside, as used herein, refers to a nucleoside which exhibits an EC50 of 15 micromolar o
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