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  • Such agents include, but are not limited to tissue specific monoclonal antibodies, methotrexate and growth factors, such as FGF, EGF, HBEFG, that can be modified whereby internalization does not occur or is reduced and other such growth factors that bind to receptors that are present in greater amounts or concentrations on neoplastic or tumorous cells or tissues than non-tumorous or non-neoplastic
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