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  • Multiple studies have shown that diseases in which TNF-?? is a mediator of inflammation respond to thalidomide treatment, including HIV-associated oral and esophageal aphthous ulcerations and cachexia, Beh??et disease, cutaneous lupus erythematosus, pyoderma gangrenosum, rheumatoid arthritis, ankylosing spondylitis, sarcoidosis, systemic lupus erythematosis, Sjogren syndrome, multiple myeloma, gra
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