Sensations and pain may occur in the upper or lower limbs and move toward the trunk, such as from the feet to the calves.Peripheral neuropathy may cause: Numbness or reduced sensationTinglingPain, often a burning or sharp, cutting sensationSensitivity to touchMuscle twitchesMuscle weaknessDifficulty with walkingLoss of coordination or balanceParalysisIf untreated, peripheral neuropathy can lead to