environment e.g. viscosity, pH which play a role in sickling process41RamanInelastic scattering from molecular vibrations (molecule in ground state)Can probe molecular structures Resolution, cellular level ??? 100 s ??mLabel freeSensitivity to in vivo cell hydration, gelation and capillary oxygen saturation should be useful in SCD Weak signals42???45CARSInelastic scattering from molecular vibrati