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  • Pemphigus is a complex T-cell???dependent autoimmune disease (mainly of autoreactive TH2 cells), which also involves a proinflammatory array of cytokines of the innate immune system, such as TNF and IL-1 and IL-6 activated proteases, and the enhancement of acantholysis.22- 27 Thus, the marked association between osteoporosis and pemphigus may be explained at the molecular level by the immunopathog
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