We found that the ancient Glutamate family is present in almost all eukaryotic lineages except in plants and in the Fungi subkingdom Dikarya, which include Ascomycota and Basidiomycota (see Figure 6).Interestingly, the conserved length and the nature of the functional domains within the N-termini across all eukaryotic lineages in which the Glutamate receptors were found suggest that the endogenous