We included the following list of independent variables (again chosen a priori): exposure to sedative medications, such as benzodiazepines and dexmedetomidine, use of restraints or restraining lines (such as a temporary pacemaker, femoral arterial catheter, intra-aortic balloon pump, or ventricular assist device), daily CV SOFA score, and mental status (normal, delirious or comatose) on the previo