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  • It may be prudent to examine blood ammonia levels in patients in whom the onset of hypothermia has been reported [see Warnings and Precautions (5.9), (5.11) or Clinical Pharmacology (12.3)]. 7.2 CNS Depressants Concomitant administration of TOPAMAX?? and alcohol or other CNS depressant drugs has not been evaluated in clinical studies.
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