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  • Polyvalent cations such as zinc, copper, tin and aluminum are known antimicrobial agents and have long been used in cosmetic, dental and pharmaceutical applications (see, for example, S. S. Block, Sterilization and Preservation, 1983; JP 63,250,309 and U.S. Pat. No. 5,037,634 to Williams et al.; see also U.S. Pat. No. 4,332,791 to Raaf et al.)
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