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  • Alternatively, epigenetic inactivation of P-gp can occur by DNA methylation at specific nucleotide sequences within the promoter sequence, called CpG islands, as has been observed in some cancer tissues [Article:15326379]; or downregulation of P-gp can also occur by mechanisms other than by DNA methylation, for example, in response to cobalamin, a vitamin B-12 derivative [Article:17982279].
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