11/292707International Classification: B01D 15/08U.S. Classification: 210656000, 210198200, 436161000, 422070000, 435007100Abstract: The invention provides extraction columns for the purification of an analyte (e.g., a biological macromolecule, such as a peptide, protein or nucleic acid) from a sample solution, as well as methods for making and using such columns.