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  • Mast cell degranulation releases vasoactive substances, including histamine, which sustain the reaction by depositing additional immune complexes.The ???itch-scratch??? cycle induces mast cell degranulation and cytokines that may respond to antihistamines.The data from guinea pigs were confirmed in the human system; IL - 8-activated neutrophils stimulated degranulation, and this was inhibited by e
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