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  • Patients should be informed of the signs and symptoms of ulcerations and bleeding, and to seek immediate medical advice if they observe any signs or symptoms that are indicative of these disorders, including epigastric pain, dyspepsia, melena, and hematemesis. [see Warnings and Precautions (5.4)]. 17.4 Hepatic Effects Patients should be informed of the warning signs and symptoms of hepatotoxicity
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