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  • ascular endothelium21 and reduced extravasation into areas of inflammation.20-22 CCR2-deficient mice develop normally and are not severely immunocompromised,20-22 but show a reduced susceptibility to a variety of inflammatory disorders,20-28 including T-cell???mediated disorders such as experimental autoimmune encephalomyelitis (EAE)29,30 and dextran sodium sulfate-induced colitis.31 Although a re
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