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  • HIT and the ??-opioid peptide DADLE can induce hibernation like states in non-hibernating mammals, and mammalian hibernation is associated with an improvement in tissue resistance to stressors such as hypoxia.Many parallels exist between SLP and hibernation: hibernation is normally triggered by endogenous ??-opioid agonism, which can also induce hibernation in non-hibernating primates [96,97]; ??-
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