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  • Caution in recent MI or unstable heart disease; hyponatremia; although minimal adverse anticholinergic effects (compared with TCAs), use with caution in glaucoma, bladder outlet obstruction, chronic constipation, and other conditions in which adverse anticholinergic effects may exacerbate symptoms; caution in patients with moderate-to-severe renal or hepatic impairment, because of excessive blood
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