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  • Raf phosphorylates MEK at serine-217 and serine-221, and MEK phosphorylates ERK at Threonine-202 and Tyrosine-204.2,9,10 Phosphorylated ERK then promotes proliferation, growth, DNA replication, migration, and other effects by activating over a hundred different proteins throughout the cell, such as cyclin D1, p90RSK, and myosin light chain kinase.2,3,10-12 This is a very important pathway in the s
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