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  • Carrageenin-induced acute inflammation is a very good model to investigate the inflammatory phase associated with the infiltration of phagocytes and overproduction of free radicals, as well as the release of inflammatory mediators such as TNF-??, COX-2, and inducible nitric oxide synthase.26 Carrageenin-induced acute inflammation reaches a peak 2 to 3 hours after injection, and the inflammation re
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