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  • Larsen's method measures the amount of destruction by assessing 32 joints, including 16 areas in both hands (eight joints in each hand), eight areas in both wrists (four joints in each wrist) and eight joints in both feet (four areas in each foot) [15].SNP selectionIn addition to the functional SNPs I50V and Q551R in the IL-4R gene, SNPs in the IL-4 and IL-13 genes were selected using a haplotype-
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