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  • The mammalian erythroblast goes even further than most differentiated cell types by enucleating and, then, ridding itself of intracellular organelles including endoplasmic reticulum, ribosomes, and mitochondria when it matures from a reticulocyte to an erythrocyte.1,2 This organelle clearance is achieved by proteasomal degradation, exocytosis of microvesicles, and autophagy.
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