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  • dulation of the enzymes that metabolize chlorination byproducts into reactive metabolites, factors such as voiding frequency and anatomic differences between the sexes, or the action of disinfection byproducts as hormone disruptors.33,34 Cytochrome P4502E1 (CYP2E1) is important in the metabolism of chloroform to active metabolites in humans35,36 and, in laboratory animals, appears to be regulated
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