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  • Adipocytes and recruited macrophages produce cytokines such as tumor necrosis factor (TNF) and interleukin 6 (IL-6) and adipokines such as adiponectin, leptin, and resistin, which are thought to be associated with obesity, insulin resistance, and related inflammatory disorders.25 Adiponectin is primarily anti-inflammatory, and leptin and resistin are proinflammatory.26 The effect of leptin on both
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