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  • Kupffer cells may also release a number of pro-inflammatory cytokines including IL-1, IL-6, IL-7, IL-17, and TNF-?? [13, 21, 57], which are markedly involved in the development of several autoimmune diseases such as rheumatoid arthritis, experimental autoimmune encephalitis, or Crohn???s disease, as well as in the development of inflammatory responses [58].
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