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  • Tumor hypoxia influences cytokines and growth factors such as Transforming growth factor-beta (TGF-b), stromal cell- derived factor-1 (SDF-1), matrix metalloproteinase (MMP), vascular endothelial growth factor (VEGF), and hypoxia-inducible factor-1 alpha (HIF-1??), which have consistently been shown to directly impact tumor behavior [2???5].
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