Results reported by R. Okazaki et al. in Endocrinology 140: 5060-5065 (1999) point to a local mechanism on bone marrow cells as well as a systemic one on glucose metabolism Nonlimiting examples of PPAR??, activators include the glitazones, such as troglitazone, pioglitazone, rosiglitazone, and BRL 49653.