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  • These cells release a variety of mediators of inflammation that cause bronchoconstriction, edema and mucus secretion, including histamine, leukotrienes, prostaglandins, Substance P. platelet activating factor, Interleukin-8, proteases, and cytokines such as GM-CSF, TNF-alpha, Interleukin-3, 4, 5 and 10.
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