metabolic disorders, such as diabetes and obesity cardiovascular disorders, such as hypertension glaucoma inflammatory disorders, such as arthritis or asthma immune disorders bone disorders, such as osteoporosis cancer intra-uterine growth retardation apparent mineralocorticoid excess syndrome (AME) polycystic ovary syndrome (PCOS) hirsutism acne oligo- or amenorrhea adrenal cortical adenoma and c