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  • High cytokines also means elevated TGF??-1 and increased levels of MMP-9, IL-1?? and PAI-1.MMP-9 or Matrix metallopeptidase 9 is an enzyme which is part of the Extracellular Matrix and is responsible for aspects of tissue remodeling; in particular it degrades certain collagens and may help in the formation of blood cells[18].
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