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  • brain also affected in Alzheimer's disease. [110,134,156] Most such studies have examined acute immune effects in moderate to severe TBI, but a few are concerned with chronic immune responses as well. [70,79,84,98,208,211] Likewise, there are a number of studies, both in human beings and experimental animals, demonstrating a massive acute accumulation of glutamate, aspartate, and other excitotoxin
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