An agent that modulates HATF-1 or HRP-1 protein activity can be an agent as described herein, such as a nucleic acid or a protein, a naturally-occurring target molecule of an HATF-1 or HRP-1 protein (e.g., an HATF-1 or HRP-1 substrate), an HATF-1 or HRP-1 antibody, an HATF-1 or HRP-1 agonist or antagonist, a peptidomimetic of an HATF-1 or HRP-1 agonist or antagonist, or other small molecule.