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  • Initial in-house target, Crm1, is the main exporter of key tumor suppressor and growth regulatory proteins such as p53, p21, FOXO, and pRB. The firm says studies have suggested that Crm1 overexpression is linked with with poor prognosis in ovarian, cervical, pancreatic, and liver cancers, as well as osteosarcoma and gliomas.
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