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  • In others, polygenic (caused by multiple genes) or multifactorial (caused by multiple factors, such as genes and environment) inheritance appears to be involved.[2] Mutations in the COL2A1 gene (12q12-q13.2) have recently been identified in familial cases of Legg-Calve-Perthes disease.[2][3] Last updated: 1/6/2011 References
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