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  • Indeed, Arancio's group has also found that the drug rolipram, by inhibiting one of the numerous phosphodiesterases (PDEs) that help regulate cAMP, is able to restore the cAMP/PKA/CREB pathway and LTP. Rolipram is approved for use in depression and is being studied in other conditions such as multiple sclerosis and stroke, but it is not a newcomer to the memory preservation challenge.
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