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  • CRL4DCAF1 plays a role in DNA replication and, if inactivated by merlin, favors the upregulation of genes related to apoptosis and cell-cycle arrest [48].Rac1 is a member of the Rho GTPase family and regulates signaling pathways such as MAPK, JNK/SAPK, NF-k??, and PI-3K [49, 50].
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