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  • Biochemical cues are provided by reciprocal interactions between the cell, soluble bioactive agents, and the ECM. Soluble factors include growth factors, morphogenetic factors, cytokines, enzymes, and small cell-permeable molecules, such as transforming growth factors (TGF), bone morphogenetic protein (BMP), vitamin C, sodium pyruvate, retinoic acids (RAs), and other small molecules [30, 31].
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