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  • Stimulation with TLR ligands, dsRNA (TLR3), LPS (TLR4), peptidoglycans (PGN; TLR2 with TLR1/6), and viral CpG DNA (TLR9), promotes an array of immune functions in glial cells, including the secretion of proinflammatory cytokines, chemokines, type I interferons (IFN-??/??), and an increase in MHC classes I and II expression.
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