Activated microglia release a large variety of neurotoxins, including the free radicals hydrogen peroxide, superoxide, and NO, that also is able to nitrate proteins; glutamate and quinolinic acid; extracellular proteases; eicosanoids; and cytokines, such as TNF-a and IL-1b, which further increase microglial proliferation and activation, thereby increasing the release of microglial toxins So it may