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  • A review of the mediators that can be elaborated by activated mast cells reveals many that might contribute to leukocyte infiltration in LPRs, including lipid mediators such as LTB4, LTC4, LTD4, PGD2, and PAF (platelet activating factor), as well as several peptide or proteinaceous chemotactic factors (Holgate, S. T. et al., in Allergy: Principles and Practice, Vol. 1 (1988), Middleton, Jr.
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